Sulphonoamide derivatives as thromboxane antagonists

Details Sulphonoamide derivatives as thromboxane antagonists Sulphonoamide derivatives as thromboxane antagonists

C - Chemistry, Metallurgy

07

C

260/329, 260/361

C07C 311/19 (2006.01) A61K 31/19 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/63 (2006.01) C07D 307/64 (2006.01) C07D 333/34 (2006.01)

Patent

CA 1331465

SULPHONOAMIDE DERIVATIVES AS THROMBOXANE ANTAGONISTS ABSTRACT The present invention provides compounds of the formula (I): RSO2NR'BCO2H (I) or a salt or ester thereof, wherein R is a phenyl, furan or thiophene ring optionally substituted by one or two substituents which are the same or different and are chosen from halogen, nitro, cyano, trifluoromethyl, C1-4alkyl and C1-4alkoxy; R' is hydrogen or C1-4alkyl; and B is an acyclic hydrocarbon group having 6 to 9 linear carbon atoms, each linear carbon atom of B being optionally substituted by one or two C1-3alkyl groups, but provided that when B is an unbranched alkylene group and R is a phenyl ring, the phenyl ring is either disubstituted or it has only one substituent which is chosen from halogen, nitro, cyano, trifluoromethyl, C1-4alkoxy, o- or m-C1-4alkyl and p-C2-4alkyl; compositions containing them and processes for their preparation. The compounds of the present invention can be used in the treatment of thromboxane mediated diseases.

575263

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