C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/329, 260/361
C07C 311/19 (2006.01) A61K 31/19 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/63 (2006.01) C07D 307/64 (2006.01) C07D 333/34 (2006.01)
Patent
CA 1331465
SULPHONOAMIDE DERIVATIVES AS THROMBOXANE ANTAGONISTS ABSTRACT The present invention provides compounds of the formula (I): RSO2NR'BCO2H (I) or a salt or ester thereof, wherein R is a phenyl, furan or thiophene ring optionally substituted by one or two substituents which are the same or different and are chosen from halogen, nitro, cyano, trifluoromethyl, C1-4alkyl and C1-4alkoxy; R' is hydrogen or C1-4alkyl; and B is an acyclic hydrocarbon group having 6 to 9 linear carbon atoms, each linear carbon atom of B being optionally substituted by one or two C1-3alkyl groups, but provided that when B is an unbranched alkylene group and R is a phenyl ring, the phenyl ring is either disubstituted or it has only one substituent which is chosen from halogen, nitro, cyano, trifluoromethyl, C1-4alkoxy, o- or m-C1-4alkyl and p-C2-4alkyl; compositions containing them and processes for their preparation. The compounds of the present invention can be used in the treatment of thromboxane mediated diseases.
575263
Cooper David Gwyn
Ife Robert John
Slater Robert Antony
Stegmeier Karlheinz
Witte Ernst-Christian
Boehringer Mannheim Gmbh
Gowling Lafleur Henderson Llp
Smith Kline & French Laboratories Limited
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