C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/48 (2006.01) A61K 31/40 (2006.01)
Patent
CA 2622670
Compounds of formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors. In more detail, this invention refers to salts of a compound selected from (E)-(E)-N-hydroxy-3-(1-[4-(([2-(1H-indol-2yl)-ethyl]- methyl-amino)-methyl)-benzene sulfonyl]-1H-pyrrol-3-yl)-acrylamide, (E)-3-[1- (4-dimetylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-N-hydroxy-acrylamide, and (E)-N-hydroxy-3-[1-(5-pyridin-2-yl-thiophene-2-sulfonyl)-1H-pyrrol-3-yl]- acrylamide with hydrochloric acid, their hydrates and to crystalline forms of these salts and hydrates.
L'invention concerne des composés représentés par la formule (I), dans laquelle R1, R2, R3, R4, R5, R6 et R7 sont tels que définis dans la description, ainsi que des sels de ceux-ci utilisés comme nouveaux inhibiteurs efficaces de l'histone déacétylase (HDAC). Plus particulièrement, l'invention concerne des sels d'un composé sélectionné dans (E)-(E)-N-hydroxy-3-(1-[4-(([2-(1H-indol-2yl)-éthyl]-méthyl-amino)-méthyl)-benzène sulfonyl]-1H-pyrrol-3-yl)-acrylamide, (E)-3-[1-(4-dimétylaminométhyl-benzènesulfonyl)-1H-pyrrol-3-yl]-N-hydroxy-acrylamide, et (E)-N-hydroxy-3-[1-(5-pyridin-2-yl-thiophène-2-sulfonyl)-1H-pyrrol-3-yl]-acrylamide avec de l'acide chlorhydrique, leurs hydrates ainsi que des formes cristallines de ces sels et hydrates.
Baer Thomas
Beckers Thomas
Feth Martin
Hummel Rolf-Peter
Maier Thomas
4sc Ag
Gowling Lafleur Henderson Llp
Nycomed Gmbh
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