Sulphur-linked imidazole compounds for the treament of hiv

Details Sulphur-linked imidazole compounds for the treament of hiv Sulphur-linked imidazole compounds for the treament of hiv

C - Chemistry, Metallurgy

07

D

C07D 233/84 (2006.01) A61K 31/4164 (2006.01) A61K 31/4439 (2006.01) A61P 31/18 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2562846

This invention relates to isophthalonitrile derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R3 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives.The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof.

Cette invention se rapporte à des dérivés d'isophtalonitrile représentés par la formule (I) ou à des sels, solvate ou dérivés de ceux-ci acceptables sur le plan pharmaceutique, les éléments R?1¿ à R?3¿ étant définis dans les pièces descriptibles de la demande, ainsi qu'à des procédés de préparation de ces dérivés, à des intermédiaires utilisés dans leur préparation et à des compositions contenant ces dérivés et aux utilisations de ces dérivés. Ces composés se fixent à l'enzyme transcriptase inverse et constituent des modulateurs, notamment des inhibiteurs de cette enzyme.

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