Supar stimulating activity of tcupa-mediated fibrinolysis...

A - Human Necessities – 61 – K

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A61K 38/49 (2006.01) A61K 38/17 (2006.01) A61P 7/02 (2006.01) A61P 7/10 (2006.01)

Patent

CA 2368183

The present invention relates to a complex (tcuPA/suPAR) of the two chain urokinase plasminogen activator (tcuPA) with the soluble urokinase plasminogen activator (suPAR), to pharmaceutical compositions comprising this complex and to different uses of the compositions in the treatment and/or prevention of thrombotic events, particularly those associated with the formation of fibrin clots. In the complex (tcuPA/suPAR), the suPAR stimulates fibrinolytic activity mediated by tcuPA under physiological conditions. The complex acts preferably on freshly-formed clots and is specific to such clots.

Cette invention, qui a trait à un complexe (tcuPA/suPAR) constitué de l'activateur de plasminogène du type urokinase bicaténaire (tcuPA) et de l'activateur de plasminogène du type urokinase soluble (suPAR), porte également sur des compositions pharmaceutiques renfermant ce complexe et sur les différents usages qui sont faits de ces compositions dans le traitement et/ou la prévention de manifestations thrombotiques, notamment celles associées à la formation de caillots de fibrine. Dans le complexe tcuPA/suPAR, le suPAR stimule l'activité fibrinolytique induite par le tcuPA sous certaines conditions physiologiques. Ce complexe, qui agit, de préférence, sur des caillots récemment formés, est spécifique de ces caillots.

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