C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 259/00 (2006.01) C07D 257/00 (2006.01)
Patent
CA 2705761
The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic 16-membered macrocyclic complexes that catalytically dismutate superoxide. It also relates to methods of using these complexes to reduce the concentration or the effects of superoxide, pharmaceutical compositions comprising these compounds or their metal complexes, and methods of treating conditions associated with excessive superoxide activity.
L'invention concerne des composés qui sont efficaces comme catalyseurs pour dismuter un superoxyde et, plus particulièrement, les complexes de manganèse ou de fer de complexes macrocycliques à 16 chaînons hétérocycliques insaturés, substitués qui dismutent catalytiquement le superoxyde. Elle concerne également des procédés d'utilisation de ces complexes pour réduire la concentration ou les effets du superoxyde, des compositions pharmaceutiques comprenant ces composés ou leurs complexes de métal, et des procédés de traitement d'affections associées à une activité excessive du superoxyde.
Kereos Inc.
Smart & Biggar
LandOfFree
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