Supercritical co2 extraction of cyclosporin a

Details Supercritical co2 extraction of cyclosporin a Supercritical co2 extraction of cyclosporin a

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) C07K 1/14 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2108655

TITLE Supercritical CO2 Extraction of Cyclosporin A ABSTRACT A process is provided for supercritical carbon dioxide extraction of cyclosporine from fungal mycelia, wherein supercritical carbon dioxide pressure does not fall below 34 MPa, throughout cyclosporine extraction from fungal mycelia. In another aspect, a process is provided for supercritical carbon dioxide extraction of cyclosporine from fungal mycelia, wherein supercritical carbon dioxide pressure is extracted at or above 35 MPa. In yet another aspect, there is provided a process for supercritical carbon dioxide extraction of cyclosporine from fungal mycelia, wherein an effective amount of ethanol is included as an cyclosporine extraction yield-enhancing co-solvent in the supercritical co-solvent fluid. These processes permit cyclosporine extraction to be managed with a greater degree of economic control over the need for and use of processing facilities, especially as related to co-extracted impurity removal.

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