Superior thrombomodulin analogs for pharmaceutical use

Details Superior thrombomodulin analogs for pharmaceutical use Superior thrombomodulin analogs for pharmaceutical use

C - Chemistry, Metallurgy

07

K

C07K 14/745 (2006.01) A61K 38/36 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2648350

The present invention relates to the use of analogs of thrombomodulin ("TM") that have the ability to enhance the thrombin-mediated activation of protein C but which have a significantly reduced ability to inhibit the direct procoagulant activities of thrombin, such as, for example, thrombin-mediated conversion of fibrinogen to fibrin. These analogs are useful in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods or inhibiting thrombotic activity are disclosed. Included are methods for increasing the circulating half life of the proteins.

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