Supplemented matrices for the repair of bone fractures

Details Supplemented matrices for the repair of bone fractures Supplemented matrices for the repair of bone fractures

A - Human Necessities

61

L

A61L 27/22 (2006.01) A61L 27/12 (2006.01)

Patent

CA 2592973

Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non- covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The matrices are biocompatible and biodegradable and can be formed in vitro or in vivo, at the time of implantation. The PTH may be a part of a fusion peptide. PTH can be incorporated into the matrices with full retention of its bio-activit y. PTH can be releasably incorporated, using techniques that provide control over how and when and to what degree the PTH is released using the matrix as a controlled release vehicle to heal bone fractures.

L'invention concerne des matrices enrichies comprenant une PTH incorporée sous une forme libérable, contenant éventuellement une matière granulée. La PTH est incorporée à la matrice soit par liaison covalente, soit par interaction non covalente avec la matrice et/ou avec les granules. Ces matrices enrichies permettent de réduire le temps de consolidation par comparaison aux autogreffes et/ou d'activer la consolidation des fractures osseuses qui ne se consolideraient pas autrement. Ces matrices sont biocompatible, biodégradables, et peuvent être formées in vitro ou in vivo, au moment de leur implantation. La PTH peut former une partie d'un peptide hybride. La PTH peut être incorporée dans les matrices tout en conservant intégralement sa bioactivité. Elle peut être incorporées de manière libérable au moyen de procédés permettant de déterminer la manière, le moment, et le degré de libération de la PTH, la matrice servant de véhicule pour la libération régulée, afin de consolider les fractures osseuses.

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