A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/00 (2006.01) A61K 38/18 (2006.01) A61K 38/36 (2006.01) A61K 47/42 (2006.01) A61L 15/32 (2006.01) A61L 24/00 (2006.01) A61L 26/00 (2006.01) A61L 27/34 (2006.01) A61L 27/50 (2006.01) A61L 25/00 (1995.01)
Patent
CA 2158134
This invention provides supplemented and unsupplemented tissue sealants (TSs), such as fibrin glue, as well as methods of their production and use. In one embodiment, this invention provides TSs that do not inhibit full thickness skin wound healing. This invention also provides growth factor(s)- and/or drug(s)- supplemented TSs and methods of their production and use. The particular drug(s) or growth factor(s) selected is a function of its use. In one embodiment, the TS is supplemented with a growth factor(s) and can be used to promote: wound healing, such as that of skin or bone; endothelialization of vascular protheses; the proliferation and/or differentiation of animal cells; and/or the directed migration of animal cells. Exemplified embodiments include fibrin glue that is supplemented with: fibroblast growth factor-1, -2 or -4; and/or bone morphogenetic proteins; and polytetrafluorethylene vascular grafts pressure perfused with fibrin glue containing HBGF-1. In another embodiment the supplemented TS is used to produce a localized delivery of a growth factor(s) and/or a drug(s). Exemplified embodiments include fibrin glue supplemented with solid 5-fluorouracil or free base tetracycline. In another embodiment, this invention provides TS supplemented or treated with a substance, such as free base tetracycline or ciprofloxacin HCl, wherein the longevity of the fibrin glue is increased.
Burgess Wilson Hales
Drohan William Nash
Greisler Howard P.
Hollinger Jeffrey O.
Lasa Carlos I. Jr.
Loyola University Of Chicago
Mbm Intellectual Property Law Llp
The American National Red Cross
The United States Of America As Represented By The Secretary Of The Arm Y.
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