G - Physics – 06 – F
Patent
G - Physics
06
F
G06F 15/401 (1990.01)
Patent
CA 2050007
Abstract of the Disclosure A system for monitoring suitability of clozapine therapy for a population of patients, including an unidentifiable sub-population subject to agranulocytosis during clozapine therapy, includes establishing a register of patients including for each patient an identified clozapine prescribing physician and a source of prescribed clozapine for example a pharmacist, as well as initial physio- logical data indicative of a physiological state of the patient prior to commencement of clozapine therapy; this data is compared with reference data to test for eligibility for clozapine therapy in accord- ance with a first set of predetermined criteria; there is identified in the register a first sub- population of patients eligible for clozapine therapy and a second sub-population which is ineligible, from each eligible patient there is obtained, at pre- determined intervals, a physiological sample from which physiological data indicative of the potential onset of agranulocytosis can be derived; a limited amount of clozapine is released to each patient for whom an obtained sample satisfies predetermined criteria which test for the onset of agranulocytosis, the limited amount being just sufficient to satisfy the dosage needs of the patient for a predetermined. interval; and, for each patient for whom the data comparison satisfies predetermined criteria, repeat- ing the cycle after the predetermined interval.
de Tenbossche Thierry P.
Derome Gilles
Gagnon Gilles
Murphy Gerard
Sandoz Canada Inc.
Swabey Ogilvy Renault
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