C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
260/210, 260/229
C07H 19/00 (2006.01) B01J 19/00 (2006.01) C07H 19/04 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01)
Patent
CA 1168229
ABSTRACT OF THE DISCLOSURE The invention described herein provides a modified inorganic polymer represented by the formula: Image wherein ? is an inorganic polymer linked to the 3' or 5' -0- of the nucleoside through a base hydrolyzable covalent bond; R is H or a blocking group; R1 is a hydrocarbyl radical containing up to 10 carbons; each 3 is a nucleoside or deoxy- nucleoside base: and each A is H or OR. Also provided by the invention as disclosed is a process for production of oligonucleotides which comprises the step of condensing the 3' -OH or 5' -OH group of a nucleoside or oligonucleotide covalently linked to an inorganic polymer by a coupling agent through the 5'-0- or 3' -0-, respectively, of said nucleoside or oligonucleotide with a phosphite compound of the formula: Image wherein R is a blocking group; 3 is a nucleoside or deoxy- nucleoside base; A is H or OR; R1 is lower alkyl; and X is Cl or Br, or a secondary amino group. The modified inorganic polymers are useful as supports for the synthesis of polynucleosides such as DNA and RNA, and also polypeptides.
371946
Caruthers Marvin H.
Matteucci Mark D.
Gowling Lafleur Henderson Llp
University Patents Inc.
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