A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) C07K 14/00 (2006.01) C12N 9/00 (2006.01) C12N 15/62 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2726092
The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/ or lung cancer. The therapy employs use of anon-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell.When so delivered, the protease is internalised and inhibits secretion/ transmission of growth hormonefromsaid cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
La présente invention concerne un procédé de suppression ou de traitement du cancer, notamment un procédé de suppression ou de traitement dun ou de plusieurs du cancer colorectal, du cancer du sein, du cancer de la prostate et/ou du cancer du poumon. La thérapie utilise une protéase non cytotoxique, qui cible une cellule sécrétant une hormone de croissance telle quune cellule pituitaire. Lorsquelle est ainsi délivrée, la protéase est internalisée et inhibe la sécrétion/transmission de lhormone de croissance de ladite cellule. La présente invention concerne également des polypeptides et des acides nucléiques destinés à être utilisés dans lesdits procédés.
Foster Keith
Lecane Phil
Madec Frederic
Marks Philip
Oyen Wiggs Green & Mutala Llp
Syntaxin Limited
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