C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/16 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C12N 9/50 (2006.01) C12N 9/99 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2204597
The present invention provides recombinant vectors comprising polynucleotides encoding defective monomers of HIV (e.g., HIV-1 or HIV-2) protease which are used to interfere with viral maturation. The defective monomers result in the formation of inactive protease heterodimers and thus inhibit the polyprotein processing events that are essential for viral maturation and infectivity.
La présente invention traite de vecteurs recombinants comportant des polynucléotides codant pour des monomères défectueux d'une protéase du virus de l'immunodéficience humaine (VIH-1 ou VIH-2 par exemple) utilisés pour faire obstacle à une maturation virale. Les monomères défectueux aboutissent à la formation d'hétérodimères de protéase inactifs et, partant, inhibent des phases de maturation essentielles pour la maturation et l'infectivité virales.
Babe Lilia M.
Craik Charles S.
Rose Jason R.
Smart & Biggar
The Regents Of The University Of California
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