Suppression of tumor necrosis factor alpha and vascular...

Details Suppression of tumor necrosis factor alpha and vascular... Suppression of tumor necrosis factor alpha and vascular...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 31/505 (2006.01) A61K 38/17 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2290021

Methods for treating and/or preventing a TNF-mediated disease in an individual are disclosed. Also disclosed are compositions comprising a TNF.alpha. antagonist and a VEGF antagonist. TNF-mediated diseases include rheumatoid arthritis, Crohn's disease, and acute and chronic immune diseases associated with transplantation.

L'invention concerne des procédés permettant de traiter et/ou d'empêcher une maladie associée au facteur de nécrose tumorale (TNF) chez un individu. L'invention concerne également des compositions contenant un antagoniste du TNF.alpha. et un antagoniste du facteur de croissance des cellules endothéliales vasculaires (VEGF). Parmi les maladies médiées par le TNF on trouve la polyarthrite rhumatoïde, la maladie de Crohn ainsi que des troubles immunologiques aigus et chroniques associés à une greffe.

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