Suppressive factor of allergy

Details Suppressive factor of allergy Suppressive factor of allergy

A - Human Necessities

61

K

167/45, 195/1.10

A61K 39/395 (2006.01) C07K 14/52 (2006.01) C12N 5/02 (2006.01) C12N 15/11 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1215918

SUPPRESSIVE FACTOR OF ALLERGY Abstract of Disclosure A monoclonal hybridoma cell line was constructed for the production of suppressive factor of allergy (SFA). mRNA isolated from the monoclonal hybridoma cell line was identified by its ability to direct SFA synthesis in Xenopus laevis oocytes. The SFA produced by the monoclonal hybridoma cell line and the translational product of the mRNA in the oocytes was found effective in inhibiting IgE- specific receptor expression in dilutions greater than 1:1,000 of the culture supernatant. A sensitive bioassay for SFA was developed using cultures of thymocytes in which Lyt-2 cells were blocked with monoclonal antibodies, and subsequent IgE-specific receptor expression was determined in Lyt-1 cells.

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