C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) C12N 5/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2321173
The invention relates to suppressive monocyte derived cells presenting the following characteristics: 1) increased release, with respect to normal monocyte derived cells, for instance of prostaglandins, and decreased level of expression and secretion of inflammatory and immunostimulating cytokines with respect to normal monocytes derived cells, and decreased presence, on their membrane, with respect to normal monocyte derived cells, of for instance CD80, and/or 2) presence in their nucleus of at least one exogenous nucleic acid which has been integrated in the absence of the monocyte derived cell division. The monocyte derived cells can be the active substances of the pharmaceutical compositions.
L'invention concerne des cellules suppressives dérivées des monocytes, présentant les caractéristiques suivantes: 1) dégagement accru, par rapport à des cellules dérivées de monocytes normales, par exemple de prostaglandines; niveau réduit d'expression et de sécrétion des cytokines d'immunostimulation et inflammatoires, par rapport à des cellules dérivées de monocytes normales; présence accrue, sur leur membrane, toujours par rapport aux cellules dérivées de monocytes normales, de, par exemple, CD80; et/ou 2) présence dans leur noyau d'au moins un acide nucléique exogène ayant été intégré en l'absence de division des cellules dérivées de monocytes. Lesdites cellules dérivées de monocytes peuvent être des substances actives de compositions pharmaceutiques.
Bartholeyns Jacques
Chokri Mohamed
Romet-Lemonne Jean-Loup
Fetherstonhaugh & Co.
I.d.m. Immuno-Designed Molecules
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