C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01) A61K 35/14 (2006.01) A61K 35/38 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/435 (2006.01) C07K 14/52 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C12N 5/08 (2006.01) C12N 15/19 (2006.01) C12P 21/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2124858
2124858 9309234 PCTABS00022 Natural suppressor (NS) cells secrete a soluble protein suppressor factor (SF) which suppresses the mixed lymphocyte response. NS cells as described herein are null, i.e., have the phenotype IL-2R+, CD3-, CD4-, CD8-, TCR.alpha.)-, Ig-, MAC-1-, or are double negative suppressors (DNS); i.e., have the phenotype IL-2R+, CD3+, CD4-, CD8-, TCR.alpha.)+. Both NS and SF are useful in vivo to confer immunotolerance with respect to allogeneic transplants, and to effect immunosuppresion. They also enhance engraftment of transplanted cells. A population of cells can be provided using density gradient separation techniques which is enriched in progenitor cells as identified by the presence of CD34 surface markers.
Board Of Trustees Of The Leland Stanford Junior University
Osler Hoskin & Harcourt Llp
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