C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 35/18 (2006.01) A61K 38/17 (2006.01) C07K 1/16 (2006.01) C07K 14/47 (2006.01) C07K 14/725 (2006.01) C12N 5/08 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2159595
The present invention relates to a bioactive molecule, herein referred to as the CD8 suppressor molecule, that is produced by the CD8 subset of human T-lymphocytes and suppresses type-1 human immunodefiency virus (HIV-1) replication through inhibition of viral transcription. The invention relates to isolation of clonal CD8 cell lines that produce the antiviral activity and the development of an assay system for detection of the antiviral activity. The clonal cell lines and the assay system, described herein, may be utilized to purify, characterize and clone the CD8 suppressor molecule. The CD8 suppressor molecule may have therapeutic applications for treatment of diseases associated with HIV-1 infection.
Bolognesi Dani P.
Chen Chin-Ho
Greenberg Michael L.
Weinhold Kent
Duke University
Osler Hoskin & Harcourt Llp
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