Supracolonic aerodigestive neoplasm detection

Details Supracolonic aerodigestive neoplasm detection Supracolonic aerodigestive neoplasm detection

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2394921

The invention provides methods and materials for detecting supracolonic aerodigestive premalignant and malignant neoplasms. Specifically, the invention provides methods and materials for determining whether a stool sample from a mammal contains a neoplasm-specific marker from a neoplasm located in the supracolonic aerodigestive tissue of a mammal. These neoplasm- specific markers are selected from the group consisting of nucleic acids having a point mutation (K-ras, APC, p53), nucleic acids that reflect microsatellite instability (BAT-26), and high integrity nucleic acids (DNA longer than 200 bp).

Cette invention se rapporte à des procédés et à des substances servant à détecter les néoplasmes malins et prémalins aérodigestifs supracoliques. Cette invention concerne spécifiquement des procédés et des substances permettant de déterminer si un échantillon de selles prélevé sur un mammifère contient un marqueur spécifique d'un néoplasme situé dans les tissus aérodigestifs supracoliques du mammifère.

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