Supramolecular pairing system, its preparation and use

Details Supramolecular pairing system, its preparation and use Supramolecular pairing system, its preparation and use

C - Chemistry, Metallurgy

07

D

C07D 239/54 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07D 473/34 (2006.01) C07K 7/06 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2301641

The invention relates to a compound of formula (I), wherein R1 is NR3R4, OR3 or SR3 with R3 and R4 being H or CnH2n+1 independently of each other and being the same or different, n being a whole number from 1 to 12; R2 is equal to CmH2m-C(X)-Y with X being =O, =S or =N, Y being equal to OR3, NR3R4 or SR3, R3 and R4 having the same meaning given above, and m being a whole number from 1 to 4; or R2 is equal to CmH2m-Z-Y' with Z being a sulfonyl, phosphonyl, ether or amine group, Y' being equal to H, CnH2n+1, OR3, NR3R4 or SR3 then Z is sulphonyl or phosphonyl group, n, R3 and R4 having the meaning given above, and Y' being equal to CnH2n+1 when Z is an ether or an amine group; A, B, and D are the same or different and mean CR5R6, O, NR7 ou S independently of each other with R5, R6 and R7 being H or CnH2n+1, independently of each other, n having the meaning given above; and C is equal to CR8 or N with R8 having the meaning of R5 independently, A-B, B-C or C-D not being two identical heteroatoms; and nucleobase means thymine, uracile, adénine, cytosine, guanine, isocytosine, isoguanine, xanthine or hypoxanthine. The invention also relates to a method for producing these derivatives and to their use in pairing and/or testing systems.

L'invention concerne un composé de formule (I) dans laquelle R?1¿ désigne NR?3¿R?4¿, OR?3¿ ou SR?3¿, R?3¿ et R?4¿ étant identiques ou différents, indépendamment l'un de l'autre et désignant H ou C¿n?H¿2n+1?, n valant un nombre entier compris entre 1 et 12; R?2¿ désigne C¿m?H¿2m?-C(X)-Y, X désignant = O, =S ou =N; Y désigne OR?3¿, NR?3¿R?4¿ ou SR?3¿, R?3¿ et R?4¿ ayant la signification mentionnée ci-dessus; et m vaut un nombre entier compris entre 1 et 4, ou R?2¿ désigne C¿m?H¿2m?-Z-Y', Z désignant un groupe sulfonyle, phosphonyle, éther ou amine, étant entendu que si Z désigne un groupe sulfonyle ou phosphonyle, Y' désigne H, C¿n?H¿2n+1?, OR?3¿, NR?3¿R?4¿ ou SR?3¿, n, R?3¿ et R?4¿ ayant la signification mentionnée ci-dessus, et si Z désigne un groupe éther ou amine, Y' désigne C¿n?H¿2n+1?; A, B et D sont identiques ou différents et désignent indépendamment les uns des autres, CR?5¿R?6¿, O, NR?7¿ ou S, R?5¿, R?6¿, R?7¿ désignant indépendamment les uns des autres, H ou C¿n?H¿2n+1?, n ayant la signification mentionnée ci-dessus; et C désigne CR?8¿ ou N, R?8¿ ayant indépendamment la signification de R?5¿, A-B, B-C ou C-D ne désignant cependant pas deux hétéroatomes identiques; et nucléobase désignant thymine, uracile, adénine, cytosine, guanine, isocytosine, isoguanine, xanthine ou hypoxanthine. L'invention concerne en outre la préparation et l'utilisation de ces dérivés dans des systèmes d'appariement et/ou de test.

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