Supression of pneumocystis carinii using aerosolized...

A - Human Necessities – 61 – K

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167/271

A61K 31/155 (2006.01) A61K 9/12 (2006.01)

Patent

CA 1334384

A method of preventing acute Pneumocystis carinii infections in immunocompromised humans is provided wherein an aerosol of pentamidine is administered to the patient in a manner which delivers the aerosol to the patient's alveoli. Also provided is a method of treating Pneumocystis carinii pneumonia in HIV seropositive individuals comprising administering a therapeutically effective amount of pentamidine aerosol to the HIV positive individual through inhalation. In addition, a method is provided of administering pentamidine to a human comprising aerosolizing a pentamidine solution in a nebulizer system having a one-way valve disposed between the nebulizer and the mouthpiece of the nebulizer system.

587045

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