Surface complexed lymphotoxin

Details Surface complexed lymphotoxin Surface complexed lymphotoxin

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 2/00 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2086264

This invention relates to a membrane associated protein, p33, and the complex it farms with a soluble lymphotoxin. These proteins are found on the surface of a number of cells, including phorbol ester (PMA) stimulated T cell hybridoma II-23.D7 cells. These proteins and complexes are useful as anti-inflammatory agents, enhancers of tumor infiltrating lymphocytes, tumor growth inhibiting agents, T cell inhibiting agents and T cell activating agents.

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