B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
182/2, 252/40, 1
B01J 20/32 (2006.01) B01D 15/08 (2006.01) B01D 15/38 (2006.01) B01J 20/286 (2006.01) C12N 11/08 (2006.01)
Patent
CA 1223859
ABSTRACT OF THE DISCLOSURE A particulate support for the manufacture of adsorbants for affinity chromatography on a column, said support being essentially constituted by particles of a basic polymeric material adapted to be used in column chromatography and on which are grafted, essentially at the surface, molecules of at least one unsaturated monomer capable of forming a copolymer with the basic material and bearing at least one chemical function capable of forming, subsequently, under non-denaturing conditions, a covalent bond with the ligand used in the adsorption envisaged, the amount of grafted monomer possessing a chemical function accessible per unit of surface area (monomer assayed per unit of surface area) being from 10 to 500 µg per cm2 of surface area of the support and the ratio of the amount of grafted monomer possessing an accessible chemical function to the total amount of grafted monomer (assayed monomer/weighed monomer) being from 0.05 to 0.5. The support of the invention may be obtained by radiochemical grafting, using radiations emitted by electron accelerators or cobalt 60 sources. An adsorbant for affinity chromatog- raphy is obtained by covalent fixation on the support of a ligand specific of the substance to be extracted or eliminated, in particular from blood.
438996
Collin Claude
Dumont Christophe
Duval Dominique
Gaussens Gilbert
Kirzenbaum Mareck
Commissariat A. L'energie Atomique
Goudreau Gage Dubuc
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