Surface membrane proteins and their effect on immune response

Details Surface membrane proteins and their effect on immune response Surface membrane proteins and their effect on immune response

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 1/22 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2176208

p74 is a protein found in T-cells and other cells, which when bound with specific agents results in inhibition of cytolytic activity and differentiation of CTLs. p74 can be isolated from T-cells and other cells using palindromic HLA-B2702.84-75-84 peptide by affinity binding of a cell 1ysate.

La protéine p74 se rencontre dans les lymphocytes T et d'autres cellules. Lorsqu'elle est liée à certains agents, elle produit une inhibition de l'activité cytolytique et de la différenciation des lymphocytes T cytotoxiques. La p74 peut être isolée des lymphocytes T et d'autres cellules à l'aide d'un peptide HLA-B2702.84-75-84 palindromique, par la liaison d'affinité d'un lysat cellulaire.

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