A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 33/08 (2006.01) A61L 27/34 (2006.01) A61L 29/08 (2006.01) A61L 31/10 (2006.01)
Patent
CA 2368162
Methods of improving the surface characteristics of a medical device or instrument, and the devices and instruments improved thereby, are provided. The disclosed methods involve the chemical attachment of an activated hyaluronic acid, such as hyaluronic acid reacted with a carbodiimide, onto the surface of the device. The hyaluronic acid can be modified to include the presence of Fe+3 or Al+3 cations to prevent calcification of the device and surrounding tissue. The devices and instruments are particularly useful during a surgical procedure.
L'invention concerne des procédés permettant d'améliorer les caractéristiques de surface d'un dispositif ou d'un instrument médical, ainsi que les dispositifs et instruments ainsi améliorés. Les procédés selon l'invention impliquent la fixation chimique d'un acide hyaluronique activé, tel qu'un acide hyaluronique que l'on a fait réagir avec une cyanamide, sur la surface du dispositif. L'acide hyaluronique peut être modifié de manière à renfermer des cations Fe¿+3? or Al¿+3? destinés à empêcher la calcification du dispositif et des tissus environnants. Ces dispositifs et instruments sont particulièrement utiles dans le cadre d'une intervention chirurgicale.
Miller Robert J.
Wan Barbara
Genzyme Corporation
Gowling Lafleur Henderson Llp
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