Surface-modified microparticles and methods of forming and...

Details Surface-modified microparticles and methods of forming and... Surface-modified microparticles and methods of forming and...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/50 (2006.01) A61K 31/7105 (2006.01) A61K 38/27 (2006.01) A61K 38/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2604225

Surface-modified microparticles and methods of making and using such particles are disclosed. The surface modified microparticles include a preformed or core microparticle that contains at least one active agent. The outer surface of the preformed or core microparticle carries a net surface charge. A monolayer is associated with the outer surface of the preformed or core microparticle. The monolayer includes at least one charged compound that has a charge that is different from the net surface charge of the preformed or core microparticle.

L'invention concerne des microparticules à surface modifiée ainsi que des procédés de fabrication et d'utilisation associés. Ces microparticules à surface modifiée comprennent une microparticule préformée ou centrale qui contient au moins un agent actif. La surface extérieure de cette microparticule préformée ou centrale transporte une charge de surface nette. Une monocouche est associée à la surface extérieure de la microparticule préformée ou centrale. Cette monocouche contient au moins un composé chargé présentant une charge différente de la charge de surface nette de la microparticule préformée ou centrale.

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