C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/085 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2446294
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface proteins of Gram-positive bacteria, and these consensus sequences include amino acid sequences such as LPXTG (SEQ ID NO: 13), ALKTGKIDIIISGMTSTPERKK (SEQ ID NO: 14), VEGAVVEKPVAEAYLKQN (SEQ ID NO: 15), and EYAGVDIDLAKKIAK (SEQ ID NO : 16). By virtue of the highly conserved regions, the sequences and the proteins including these sequences can be utilized to generate antibodies which can recognize these highly conserved motifs and the proteins containing them and thus be useful in the treatment or prevention of a wide range of infections caused by Gram-positive bacteria.
L'invention concerne des séquences peptidiques isolées et des protéines contenant ces séquences, utilisées pour prévenir et traiter les infections par bactéries Gram positif. Il a été démontré que ces séquences peptidiques comportent des motifs fortement conservés au niveau des protéines de surface des bactéries Gram positif. Ces séquences consensuelles comportent des séquences d'acides aminés, par exemple, LPXTG (SEQ ID NO: 13), ALKTGKIDIIISGMTSTPERKK (SEQ ID NO: 14), VEGAVVEKPVAEAYLKQN (SEQ ID NO: 15), et EYAGVDIDLAKKIAK (SEQ ID NO: 16). En raison des régions fortement conservées, ces séquences ainsi que les protéines qui les comportent peuvent servir à mettre au point des anticorps qui reconnaissent à la fois ces motifs fortement conservés et les protéines qui les renferment. Par conséquent, ces séquences sont utiles dans le traitement ou la prévention d'un large éventail d'infections produites par des bactéries Gram positif.
Hook Magnus A. O.
Xu Yi
Blake Cassels & Graydon Llp
The Texas A. & M. University System
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