C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 31/7088 (2006.01) A61K 39/09 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) C07K 7/04 (2006.01) C07K 14/135 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2443493
.beta.-hemolytic streptococci polynucleotides, polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, and antibodies of these polypeptides are described. The polynucleotides, polypeptides, and antibodies of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing .beta.-hemolytic streptococcal infection, and for detecting .beta.-hemolytic streptococci in a biological sample.
La présente invention concerne des polynucléotides et des polypeptides de streptocoques hémolytiques de type .beta., et en particulier des polypeptides et des polynucléotides de Streptococcus pyogenes et des anticorps de ces polypeptides. Ces polynucléotides, ces polypeptides et ces anticorps peuvent être préparés en vue d'être utilisés comme compositions immunogènes. Cette invention concerne aussi des techniques d'immunisation contre une infection par streptocoques hémolytiques de type .beta. et de réduction de ce type d'infection. Ces techniques permettent aussi de détecter des streptocoques hémolytiques de type .beta. dans un échantillon biologique.
Nickbarg Elliott Bruce
Olmsted Stephen Bruce
Winter Laurie Anne
Zagursky Robert John
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Wyeth
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