Susceptibility gene for myocardial infarction

Details Susceptibility gene for myocardial infarction Susceptibility gene for myocardial infarction

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2502359

Linkage of Myocardial Infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by association analysis to be a susceptibility gene for MI. Pathway targeting for drug delivery and diagnosis applications in identifying those have MI or at risk of developing MI, in particular are described.

L'invention concerne la liaison entre un infarctus du myocarde (IM) et un site du chromosome 13q12. L'invention concerne en particulier le gène FLAP de ce site qui, par analyse d'association, s'est révélé être un gène de susceptibilité d'un infarctus du myocarde (IM). L'invention concerne tout particulièrement le ciblage d'une voie d'administration de médicaments, ainsi que des applications de diagnostic permettant d'identifier les personnes atteintes d'un infarctus du myocarde ou susceptibles de développer un infarctus du myocarde (IM).

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