Susceptibility genes for age-related maculopathy (arm) on...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01)

Patent

CA 2609017

Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of ARM in an individual that comprises identification of allelic variations in PLEKHA1 and/or LOC387715. Related apparatus, such as an array, are identified as being useful in implementing those methods.

Selon l'invention, des variations alléliques dans les gènes PLEKHA1 et LOC387715 sont identifiées comme facteur de risque d'une dégénérescence maculaire liée à l'âge (DMLA). L'invention concerne notamment un procédé d'identification d'un risque de développement d'une DMLA chez un individu, ce procédé consistant à identifier des variations alléliques dans les gènes PLEKHA1 et/ou LOC387715. Un appareil associé, tel qu'un jeu ordonné d'échantillons, s'avère utile pour mettre en oeuvre ce type de procédé.

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