Sushi peptides, processes for making and uses thereof

Details Sushi peptides, processes for making and uses thereof Sushi peptides, processes for making and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/48 (2006.01) A61K 38/48 (2006.01) C12N 9/64 (2006.01) C12N 11/10 (2006.01) C12P 21/00 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2432972

Endotoxin, also known as lipopolysaccharides (LPS), is the major mediator of septic shock due to Gram-negative bacterial infection. Chemically synthesized S3 peptide, derived from Sushi3 domain of Factor C, which is the endotoxin-sensitive serine protease of the limulus coagulation cascade, binds and neutralizes LPS activity. Fluorescent tagged-S3 is shown to detect LPS-containing bacteria. For large-scale production of S3 and to mimick other pathogen-recognizing molecules, tandem multimers of the S3 gene were constructed and expressed in E. coli. Tetramer of S3 is shown to display an enhanced inhibitory effect on LPS-induced activities. An affinity matrix bases on tetramer of S3 is also shown to be particularly efficient at removing LPS.

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