A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 31/5377 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2514548
The present invention is directed to a suspension vehicle for coated drug particles. The coated drug particles are suitable for use in taste masking. The suspension vehicle disclosed enables the maintenance of coated drug particles with an average particle size of about 50 ~m to about 600 ~m in suspension for an extended period of time, without sedimentation or floating, even after shaking in the presence of air. The suspension vehicle of the present invention makes it possible to produce multidose oral suspensions of coated drugs, from which consistent dosages can be dispensed over time. The dry formulations, methods, and suspension vehicles of the present invention are particularly well suited for the delivery of objectionable tasting drugs, such as linezolid.
L'invention concerne un excipient de suspension destiné à des particules de médicaments revêtues. Ces particules de médicaments revêtues peuvent être utilisées dans le masquage du goût. L'excipient de suspension de l'invention permet de maintenir les particules de médicaments revêtues à une dimension de particules moyenne comprise entre environ 50 µm et environ 600 µm en suspension pour une période de temps étendue sans sédimentation ou flottement, même après secouage en présence d'air. L'excipient de suspension de cette invention permet de produire des suspensions orales multidoses de médicaments revêtues, à partir desquelles des dosages importants peuvent être distribués dans le temps. Les formulations sèches, les procédés et les excipients de suspension de cette invention sont particulièrement adaptés à l'administration de médicaments à goût indésirable, tel que le linézolide.
Fredrickson Jennifer K.
Reo Joseph P.
Pharmacia Corporation
Smart & Biggar
LandOfFree
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