Sustained analgesia achieved with buprenorphine

Details Sustained analgesia achieved with buprenorphine Sustained analgesia achieved with buprenorphine

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/70 (2006.01) A61M 37/00 (2006.01) A61P 25/36 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2276170

The use of buprenorphine in the preparation of a medicament for a method of effectively treating pain in humans is achieved by administering buprenorphine in a manner indicative of first order pharmacokinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in a manner indicative of zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.

L'invention concerne l'utilisation de buprénorphine dans la préparation d'un médicament destiné à une méthode de traitement efficace de la douleur chez les humains, la méthode consistant à administrer de la buprénorphine de manière indicative d'une pharmacocinétique de premier ordre pendant une période comprenant un intervalle initial de trois jours entre deux doses successives, de manière à atteindre une concentration de plasma maximale comprise entre 20 pg/ml et 1052 pg/ml environ; puis à poursuivre l'administration de buprénorphine pendant une période comprenant un intervalle additionnel d'au moins deux jours entre deux doses successives, de manière indicative d'une cinétique d'ordre zéro, de sorte que les patients soient sous analgésie pendant la période comprenant l'intervalle additionnel d'au moins deux jours entre deux doses successives.

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