Sustained-release composition, process for producing the...

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A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/52 (2006.01)

Patent

CA 2571583

A sustained-release composition which comprises (i) a physiologically active substance and (ii) a lactic acid-glycolic acid copolymer in which the weight- average molecular weight (Mw) is about 8,000 to about 11,500, the ratio of the weight-average molecular weight (Mw) to the number-average molecular weight (Mn) is greater than 1.9, and the compositional molar ratio of lactic acid to glycolic acid is 99.9/0.1 to 60/40, or a salt thereof, and which does not contain a drug retaining substance is provided and said sustained-release composition has improved spherical property and/or needle penetrating property.

L~invention concerne une composition à libération prolongée laquelle comprend (i) une substance physiologiquement active et (ii) un copolymère acide lactique-acide glycolique dans lequel le poids moléculaire moyen en poids (Mw) est d'environ 8 000 à environ 11 500, le rapport du poids moléculaire moyen en poids (Mw) sur le poids moléculaire moyen en nombre (Mn) est supérieur à 1,9 et la proportion molaire de composition de l'acide lactique par rapport à l'acide glycolique est de 99,9/0,1 à 60/40 ou un sel de celui-ci, et laquelle ne contient pas une substance retenant le médicament et ladite composition à libération prolongée a une meilleure propriété sphérique et/ou une meilleure propriété de pénétration dans une aiguille.

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