C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/08 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 209/08 (2006.01) C07D 213/38 (2006.01) C07D 215/12 (2006.01) C07D 217/16 (2006.01) C07D 233/64 (2006.01) C07D 239/04 (2006.01) C07D 241/04 (2006.01) C07D 241/12 (2006.01) C07D 243/04 (2006.01) C07D 243/08 (2006.01) C07D 257/04 (2006.01) C07D 263/56 (2006.01) C07D 295/084 (2006.01) C07D 295/088 (2006.01) C07D 307/52 (2006.01) C07D 307/81 (2006.01) C07D 333/20 (2006.01) C07D 333/58 (2006.01)
Patent
CA 2269328
The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and - homopiperazines, pharmaceutical compositions comprising the same, and a method of using such sustained-release derivatives to bind the dopamine transporter to achieve a desired effect, such as antagonism of dopamine reuptake inhibitors, such as cocaine, or dopamine releasers or norepinephrine and/or serotonin reuptake inhibitors, such as methamphetamine.
La présente invention concerne des dérivés à libération prolongée d'analogues hydroxylés de 1-[2[bis(aryl)méthoxy]éthyl]-pipérazines et -homopipérazines, substituées, des compositions pharmaceutiques les comprenant et une méthode d'utilisation de ces dérivés à libération prolongée pour fixer le transporteur de la dopamine en vue d'obtenir l'effet souhaité, tel que l'antagonisme des inhibiteurs du recaptage de la dopamine, tels que la cocaïne, ou des substances libératrices de la dopamine ou encore des inhibiteurs du recaptage de la norépinéphrine et/ou de la sérotonine, tels que la méthamphétamine.
Glowa John R.
Lewis David
Matecka Dorota
Rice Kenner C.
Rothman Richard B.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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