Sustained release device for treating conditions of the joint

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 31/58 (2006.01) A61K 38/13 (2006.01) A61L 31/16 (2006.01) A61M 31/00 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2427795

An implantable drug delivery system is provided including a mechanical member attachable to a portion of a body, a first chamber having an opening configured to receive a sustained release device, a sustained release device, and a removably attachable retainer for retaining the sustained release device in the first chamber. A method for administering a drug to a joint is provided including the steps of positioning a mechanical member in or adjacent a bone, the mechanical member configured to hold a sustained release drug delivery device at a substantially controlled rate. Also provided is a sustained release device intraarticularly implantable into a joint to deliver a therapeutically effective compound within a synovial capsule of the joint such that, in one aspect, the synovial fluid concentration of the compound is greater than the plasma concentration of the compound during the prolonged lifetime of the device, thereby eliminating unwanted systemic side effects and the need for frequent and repeated administrations.

L'invention concerne un système implantable d'administration de médicament, comportant un élément mécanique pouvant être fixé à une partie du corps, une première chambre comportant une ouverture configurée pour recevoir un dispositif de libération prolongée, un dispositif de libération prolongée, ainsi qu'un dispositif de retenue, fixé de manière amovible, destiné à retenir le dispositif de libération prolongée dans la première chambre. L'invention concerne également un procédé d'apport de médicament à une articulation, consistant à disposer un élément mécanique dans un os ou à proximité d'un os, cet élément mécanique étant configuré pour maintenir un dispositif d'apport de médicament à libération prolongée portant au moins un médicament qu'il libère à un débit sensiblement régulé. L'invention concerne encore un dispositif de libération prolongée implantable de manière intra-articulaire dans une articulation afin d'apporter un composé thérapeutiquement efficace à l'intérieur d'une capsule synoviale de l'articulation, de sorte que, selon un aspect, la concentration de synovie du composé soit supérieure à la concentration de plasma du composé pendant la durée de vie prolongée du dispositif, ce qui permet d'éviter ainsi des effets secondaires systémiques indésirables et la nécessité de procéder à des administrations fréquentes et répétées.

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