Sustained-release drug delivery employing a powdered...

Details Sustained-release drug delivery employing a powdered... Sustained-release drug delivery employing a powdered...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2205351

An oral-delivery pharmaceutical composition for achieving sustained release of a drug in a mammal. The composition includes (a) a suitable amount of a pharmaceutically-acceptable hydrocolloid gum obtainable from higher plants (e.g., about 20 % - 90 % by weight), (b) another excipient (e.g., about 5 % - 30 % by weight) that aids in sustained release and (c) a therapeutically- effective amount of a drug. Preferably the mean particle size of the gum is about 150µ or less. Also disclosed is a process for preparing the composition and a method for achieving sustained release of a drug by administering the composition to a subject in need thereof.

Une composition pharmaceutique à administration orale permet d'obtenir la libération prolongée d'un médicament chez un mammifère. La composition comprend (a) une quantité appropriée d'une gomme hydrocolloïde pharmaceutiquement acceptable pouvant être obtenue à partir de spermatophytes (p.ex., entre environ 20 % et 90 % en poids), (b) un autre excipient (p.ex., entre environ 5 % et environ 30 % en poids) qui facilite la libération prolongée et (c) une quantité thérapeutiquement efficace d'un médicament. De préférence, la granulométrie moyenne de la gomme est inférieure ou environ égale à 150 µ. L'invention se rapporte également à un procédé de préparation de la composition et à un procédé permettant d'obtenir une libération prolongée d'un médicament en administrant la composition à un patient nécessitant d'être traité à l'aide de celle-ci.

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