Sustained-release drug delivery system

Details Sustained-release drug delivery system Sustained-release drug delivery system

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2238930

A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a hydrophobic matrix. A hydrophilic microenvironment is created in a hydrophobic matrix by incorporating hydrophilic polymers within a hydrophobic matrix. Optionally, a binder, preferably a polyhydroyxlated compound, can also be added.

Composition pharmaceutique à libération prolongée comprenant un agent pharmaceutique hautement soluble tel que la sélégiline, dans un excipient pharmaceutique comprenant un polymère hydrophile dispersé dans une matrice hydrophobe. Un microenvironnement hydrophile est créé dans une matrice hydrophobe par incorporation de polymères hydrophiles à l'intérieur d'une matrice hydrophobe. On peut également ajouter, à titre d'option, un liant, de préférence un composé polyhydroxylé.

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