Sustained-release drug formulations for implantation

Details Sustained-release drug formulations for implantation Sustained-release drug formulations for implantation

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 47/02 (2006.01) A61K 47/34 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2384301

The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled release of active ingredients. The formulation comprises a combination of one of (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.

La présente invention concerne une formulation de constitution nouvelle destinée à l'implantation, caractérisée en ce qu'elle libère les principes actifs de façon contrôlée. Ladite formulation comprend l'une des combinaisons (a), (b) et (c) ci-après, ainsi qu'un excipient renfermant un polymère hydrophobe, la combinaison de particules étant dispersée dans l'excipient : (a) particules comprenant un principe actif, particules comprenant un carbonate, et particules comprenant une substance que l'on fait réagit avec le carbonate dans une solution aqueuse pour générer du dioxyde de carbone (substance telle qu'un acide) ; (b) particules comprenant un principe actif et un carbonate, et particules comprenant une substance telle qu'un acide ; et (c) particules comprenant un carbonate, et particules comprenant un principe actif et une substance telle qu'un acide

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