Sustained-release formulations of topiramate

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/7048 (2006.01) A61K 9/16 (2006.01) A61K 9/24 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 47/40 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2618240

Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.

L'invention concerne des compositions pharmaceutiques de topiramate pour une administration orale une fois par jour. Les formulations comprennent un composant à libération prolongée et éventuellement un composant à libération immédiate, dont les compositions peuvent être ajustées de manière sélective, respectivement, pour libérer l'ingrédient actif selon un profil de libération prédéterminé. Le procédé de traitement ou de prévention de troubles pathologiques chez des sujets mammifères comprenant l'administration des nouvelles formulations décrites ici est également fourni.

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