A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 47/30 (2006.01)
Patent
CA 2207334
This invention relates to sustained-release granular preparations obtained by wet-granulating an aqueous suspension, which comprises a medicinal ingredient, a fine particulate polymer having an average particle size not greater than 50 µm and a plasticizer, into granules and treating said granules at a temperature not less than the lower one of a minimum film-forming temperature and glass transition temperature of a mixture of said polymer and said plasticizer. This invention is also concerned with a process for the production of the sustained-release granular preparations. According to the present invention, granular preparations having an excellent sustained-release property and a high safety to the human body can be easily produced in a simple manner.
La présente invention concerne une préparation granulaire à libération prolongée qui est excellente pour ce qui concerne la diffusion lente et inoffensive pour l'organisme humain. Elle peut être produite aisément, d'une manière simple, par granulation par voie humide d'une suspension aqueuse contenant un principe actif efficace sur le plan médical, un polymère particulaire ayant un diamètre moyen de particules de 50 <m ou moins, et un plastifiant, et par traitement des granulés obtenus à la plus basse des températures suivantes: la plus basse température de formation d'un film pour un mélange du polymère et du plastifiant, et sa température de transition vitreuse.
Kojima Masazumi
Nakagami Hiroaki
Sagasaki Shinji
Daiichi Pharmaceutical Co. Ltd.
Gowling Lafleur Henderson Llp
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