A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 47/00 (2006.01)
Patent
CA 2604568
The present invention provides methods and formulations for the treatment and prevention of cerebrovascular and cardiovascular diseases and disorders. The present invention is based, at least in part, on the discovery that administering to a subject a formulation comprising an agonist of endothelial nitric oxide synthase (eNOS), such as an HMG-CoA reductase inhibitor, and a formulation comprising a precursor of NO, such as L- arginine, may be used to treat or prevent cerebrovascular and/or cardiovascular diseases or disorders.
La présente invention procure des procédés et des formulations pour le traitement et la prévention des maladies et des troubles cérébrovasculaires et cardiovasculaires. La présente invention est basée, au moins en partie, sur la découverte que l~administration à un sujet d~une formulation comprenant un agoniste de l~oxyde nitrique synthéase endothéliale (eNOS), tel qu~un inhibiteur de la HMG-CoA réductase, et d~une formulation comprenant un précurseur de NO, tel que la L-arginine, peut être utilisée pour traiter ou prévenir les maladies ou les troubles cérébrovasculaires et/ou cardiovasculaires.
Palmetto Pharmaceuticals Llc
Riches Mckenzie & Herbert Llp
Ron Eyal S.
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