Sustained-release metal valproate tablets

Details Sustained-release metal valproate tablets Sustained-release metal valproate tablets

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 9/28 (2006.01) A61K 9/36 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2250318

The present invention provides a sustained-release metal valproate tablet which is comparatively compact and is not influenced by a meal, the sustained-release metal valproate comprising a core tablet comprising a metal valproate having on the surface a coating layer comprising light silicic acid anhydride dispersed in a mixture of ethyl cellulose and a methacrylic acid-methyl methacrylate copolymer.

Cette invention concerne des comprimés à base de valproate métallique à libération prolongée, de dimensions relativement faibles, qui doivent être administrés de façon à ne pas subir l'influence des repas. Ces comprimés se caractérisent en ce qu'ils contiennent un noyau à base de valproate métallique et une couche d'enrobage formée à la surface dudit noyau, ladite couche d'enrobage étant constituée d'une dispersion d'acide silicique anhydre dans un mélange d'éthylcellulose et d'un copolymère d'acide méthacrylique et de méthacrylate de méthyle.

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