Sustained release organic nitrite therapy

Details Sustained release organic nitrite therapy Sustained release organic nitrite therapy

A - Human Necessities

61

K

A61K 31/34 (2006.01) A61K 31/21 (2006.01)

Patent

CA 2116785

A novel method of treating a patient suffering from a condition requiring vasodilator therapy, comprising long term, continuous administration of an organic nitrite to the patient in a dosage form capable of delivering a sufficient therapeutic amount of nitrite to the bloodstream of the patient thereby providing effective vasodilator therapy for at least 24 hours without development of tolerance in the patient. The method of the invention is useful in treating conditions such as angina, particularly chronic, stable angina pectoris, ischemic diseases and congestive heart failure, and for controlling hypertension and/or impotence in male patients.

Méthode innovatrice de traitement aux vasodilatateurs, comprenant l'administration continue à long terme de nitrite organique au patient sous une forme posologique capable de livrer une dose thérapeutique suffisante de nitrite dans sa circulation sanguine. Ce traitement est alors efficace pour au moins 24 heures sans que le patient ne développe de tolérance. La méthode divulguée est utile pour le traitement de conditions comme l'angine, en particulier l'angine de poitrine chronique stable, des maladies ischémiques et l'insuffisance cardiaque congestive, et pour maîtriser l'hypertension et/ou l'impuissance.

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