Sustained release particles

Details Sustained release particles Sustained release particles

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61J 3/00 (2006.01) A61K 38/00 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2234615

A method of preparing parenterally administrable sustained release microparticles, which comprises preparing core particles in an aqueous medium that is essentially free from organic solvent, a biologically active substance being entrapped therein during or after said preparation, drying the core particles and coating the same with a release- controlling polymer by air suspension technique so as to create a shell on the core particles without any detrimental exposure of the active substance to organic solvent. Microparticles obtainable by such a method.

L'invention porte sur un procédé de préparation de microparticules à diffusion prolongée administrables par voie parentérale. Ce procédé consiste à préparer des particules noyaux dans un milieu aqueux quasiment exempt de solvant organique, une substance biologiquement active y étant incluse, que ce soit pendant ou à la suite du processus de préparation, à sécher ces particules noyaux et à les enrober, par une technique de suspension pneumatique, d'un polymère régulateur de diffusion afin de constituer une enveloppe autour des particules noyaux sans que ne survienne une quelconque exposition préjudiciable de la substance active à un solvant organique. Cette invention concerne également des microparticules pouvant être obtenues par ce procédé.

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