A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5585 (2006.01) A61K 9/00 (2006.01) A61K 31/557 (2006.01) A61K 31/5575 (2006.01) A61K 47/14 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01) A61K 47/44 (2006.01)
Patent
CA 2316539
The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances containing ionic compounds having opposite charges to those of ionic prostanoic acid derivatives and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic prostanoic acid derivatives and the ionic compounds having opposite charges to those of the prostanoic acid derivatives and increasing hydrophobicity of these derivatives that contain hydrophobic groups in the molecule thereof. The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the ionic prostanoic acid derivatives, irrespective of water solubility possessed by the ionic prostanoic acid derivatives.
L'invention concerne des compositions médicinales à libération prolongée de dérivés d'acide prostanoïque ionique renfermant des composés ioniques qui sont chargés de manière opposée aux dérivés d'acide prostanoïque ionique et qui sont en mesure d'augmenter les propriétés hydrophobes de ces dérivés. Les composés ioniques sont ceux ayant un(des) groupes(s) hydrophobe(s) dans la molécule. Ces compositions médicinales peuvent faire preuve d'une action efficace à libération prolongée des dérivés d'acide prostanoïque ionique indépendamment de l'hydrosolubilité des dérivés.
Hara Michio
Katsuma Masataka
Mitomi Mitsuo
Saito Katsumi
Takagi Akira
Astellas Pharma Inc.
Dennison Associates
Toray Industries Inc.
Yamanouchi Pharmaceutical Co. Ltd.
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