Sustained release pharmaceutical dosage forms with minimized...

A - Human Necessities – 61 – K

Patent

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A61K 9/22 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2432178

A pharmaceutical composition comprising at least one pharmaceutically active agent that is pH dependent, at least one non-pH dependent sustained release agent, and at least one pH dependent agent that increases the dissolution rate of the at least one pharmaceutically active agent at a pH in excess of 5.5. Such compositions have minimized pH-dependent dissolution profiles or pH- independent dissolution profiles.

L'invention concerne une composition pharmaceutique comprenant au moins un principe actif sur le plan pharmaceutique qui est dépendant du pH, au moins un agent de libération prolongée indépendant du pH, et au moins un agent dépendant du pH qui augmente la vitesse de dissolution du principe actif sur le plan pharmaceutique à un pH de plus de 5,5. Ces compositions présentent des profiles de dissolution dont la dépendance au pH est réduite au minimum ou des profiles de dissolution indépendant du pH.

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