Sustained release ranolazine formulations

Details Sustained release ranolazine formulations Sustained release ranolazine formulations

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2343376

A sustained release ranolazine formulation contains an intimate mixture of ranolazine and a partially neutralized pH-dependent binder to form a film that is mostly insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. The formulation is suitable for twice daily administration of ranolazine and is useful for controlling the rate of dissolution of ranolazine, and to maintain human plasma ranolazine levels at between 550 and 7500 ng basNmL.

La présente invention concerne une formulation de ranolazine à libération lente qui contient un mélange intime de ranolazine et un liant à dépendance du pH et partiellement neutralisé, et ce, de façon à former un film qui est sensiblement insoluble dans un milieu aqueux de pH inférieur à 4,5, et soluble dans un milieu aqueux de pH supérieur à 4,5. Cette formulation, qui convient à une administration biquotidienne de ranolazine, permet de réguler la cadence de dissolution de la ranolazine et de maintenir la teneur de ranolazine dans le plasma humain entre 550 et 7500 ng de base/mL.

Affiliated with

Also associated with

Rating

Sustained release ranolazine formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sustained release ranolazine formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained release ranolazine formulations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1353812