Sustained release small molecule drug formulation

Details Sustained release small molecule drug formulation Sustained release small molecule drug formulation

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/519 (2006.01) A61K 45/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/22 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2624088

An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having Cmax to Cmin ratio less than 200 and lag time less than 0.2.

L'invention concerne une formulation à injection retard comprenant un polymère biocompatible, un solvant organique combiné au polymère biocompatible pour former un gel visqueux, et un médicament à petites molécules incorporé dans le gel visqueux de façon que la formulation présente un profil de libération in vivo avec un rapport Cmax à Cmin inférieur à 200 et un décalage inférieur à 0,2.

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