Sustained release suppositories and a process for preparation

Details Sustained release suppositories and a process for preparation Sustained release suppositories and a process for preparation

A - Human Necessities

61

K

A61K 9/02 (2006.01) A61K 31/485 (2006.01) A61K 47/04 (2006.01)

Patent

CA 2099557

A B S T R A C T A sustained release suppository comprising in a usual suppository base a) a water-soluble therapeutically active sub- stance, the average particle size of which is smaller than 20 µm, b) a physiologically acceptable organic substance which is swellable in contact with water, and c) hydrophobic silicium dioxide. The suppository base is usually a fat having a melting range of from 29 to 38°C. As ingredient b) cellulose derivatives such as hydroxypropylmethylcellulose may be used, in a quantity of from 5 to 40% by weight, preferably 9 to 15% by weight. Ingredient c) is preferably used in a quantity of from 3 to 6% by weight. Also a process for manufacturing the suppositories is described.

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